Adrian On-Wah Leung, Tsz-Ching Yiu, Lingxiao Liu, Hei-Yin Tam, Shen Gu, Jiajie Tu, Duanqing Pei & Hoi-Hung Cheung. Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells. Cell & Bioscience. 12:212 (2022)
Yuxin Hou, Chang Li, Chaemin Yoon, On Wah Leung, Sikun You, Xiaoming Cui, Jasper Fuk-Woo Chan, Duanqing Pei, *Hoi Hung Cheung & *Hin Chu. Enhanced replication of SARS-CoV-2 Omicron BA.2 in human forebrain and midbrain organoids. Sig Transduct Target Ther 7, 381 (2022). (*co-corresponding authors)
https://doi.org/10.1038/s41392-022-01241-2
Yuyao Tian, Wuming Wang, Sofie Lautrup, Hui Zhao, Xiang Li, Patrick Wai Nok Law, Ngoc-Duy Dinh, Evandro Fei Fang, Hoi Hung Cheung & Wai-Yee Chan. WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome. Nat Commun 13, 5456 (2022).
https://doi.org/10.1038/s41467-022-33012-6
Zhaohui Liu & Hoi-Hung Cheung. Stem Cell-Based Therapies for Parkinson Disease. Int. J. Mol. Sci. 2020; 21(21):8060.
https://doi.org/10.3390/ijms21218060
Wang Z, Miu KK, Zhang X, Wan TY, Lu G, Cheung HH, Lee HM, Kong PS, Chan JCN & Chan WY. Hepatic miR-192-3p re-activation alleviates steatosis by targeting glucocorticoid receptor. JHEP Reports. 2020 Dec; 2(6)
https://doi.org/10.1016/j.jhepr.2020.100179
Jiajie Tu, Chao Wan, Fengjie Zhang, Yuyao Tian, Lianbao Cao, Patrick Wai Nok Law, Gang Lu, Owen M. Rennert, Wai-Yee Chan & Hoi-Hung Cheung. Genetic correction of Werner syndrome gene reveals impaired pro-angiogenic function and HGF insufficiency in mesenchymal stem cells. Aging Cell. 2020 May; 19(5):e13116.
https://doi.org/10.1111/acel.13116
Wuming WANG, Gang LU, Xianwei SU, Chengcheng TANG, Hongjian LI, Zhiqiang XIONG, Chi-Kwan LEUNG, Man-Sze WONG, Hongbin LIU, Jin-Long MA, Hoi-Hung Cheung, Hsiang-Fu KUNG, Zi-Jiang CHEN, Wai-Yee CHAN. Pten-mediated Gsk3β Modulates the Naïve Pluripotency Maintenance in Embryonic Stem Cells. Cell Death Dis. 2020 Feb 7; 11(2):107.
https://doi.org/10.1038/s41419-020-2271-0
Tu J, Cheung HH, Lu G, Chan CL, Chen ZJ, Chan WY. microRNA-126 Is a Tumor Suppressor of Granulosa Cell Tumor Mediated by Its Host Gene EGFL7. Front. Oncol. 11 June 2019.
https://doi.org/10.3389/fonc.2019.00486
Cao D, Cheung HH, Chan WY. Doxycycline masks the genuine effect of the doxycycline-inducible transgene by promoting dopaminergic neuron differentiation from human pluripotent stem cells. Stem Cells Dev. 2019 Apr 25.
https://www.liebertpub.com/doi/abs/10.1089/scd.2018.0209
Tu J, Cheung AH, Chan LK and Chan WY. The Role of microRNAs in Ovarian Granulosa Cells in Health and Diseases. Front. Endocrinol. 2019 Mar 1.
https://www.frontiersin.org/articles/10.3389/fendo.2019.00174/abstract
Sofie Lautrup, Domenica Caponio, Hoi-Hung Cheung, Claudia Piccoli, Tinna Stevnsner, Wai-Yee-Chan, Evandro F. Fang. Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases. Biogerontology. 2019 Jan
https://www.ncbi.nlm.nih.gov/pubmed/30666569
Tu J, Tian G, Cheung HH, Wei W, Lee TL. Gas5 is an essential lncRNA regulator for self-renewal and pluripotency of mouse embryonic stem cells and induced pluripotent stem cells. Stem Cell Res Ther. 2018 Mar 21;9(1):71.
https://www.ncbi.nlm.nih.gov/pubmed/29562912
Jiajie Tu, Hoi-Hung Cheung, Gang Lu, Zijiang Chen, Wai-Yee Chan. MicroRNA-10a promotes granulosa cells tumor development via PTEN-AKT/Wnt regulatory axis. Cell Death & Disease. 2018 Oct 22;9(11):1076.
https://www.nature.com/articles/s41419-018-1117-5
Jiajie Tu, Pengying Zhang, Alfred Chun Shui Luk, Jason Jinyue Liao, Wai-Yee Chan, Albert Cheung Hoi-Hung* and Tin-Lap Lee*. MicroRNA-26b promotes transition from Kit- to Kit+ mouse spermatogonia. Experimental cell research. 2018 Sep 25. pii: S0014-4827(18)30585-8. (*co-corresponding authors)
https://www.ncbi.nlm.nih.gov/pubmed/30266657
Yanzhou Yang, Hoi-Hung Cheung, Cheng Zhang, Ji Wu and Wai-Yee Chan. Melatonin as Potential Targets for Delaying Ovarian Aging. Curr Drug Targets. 2018 Aug 28.
https://www.ncbi.nlm.nih.gov/pubmed/30156157
Lu Li, Kai-Kei Miu, Shen Gu, *Hoi-Hung Cheung & *Wai-Yee Chan. Comparison of multi-lineage diferentiation of hiPSCs reveals novel miRNAs that regulate lineage specification. Sci Rep. 2018. 8:9630. (*co-corresponding authors)
https://www.nature.com/articles/s41598-018-27719-0
Jiajie Tu, Dandan Cao, Lu Li, *Hoi-Hung Cheung, *Wai-Yee Chan. MicroRNA profiling during directed differentiation of cortical interneurons from human-induced pluripotent stem cells. FEBS Openbio. 2018. (*co-corresponding authors)
https://febs.onlinelibrary.wiley.com/doi/full/10.1002/2211-5463.12377
Tu Jiajie, Yang Yanzhou, Cheung Hoi-Hung, Chen Zi-Jiang & Chan Wai-Yee. Conserved miR-10 family represses proliferation and induces apoptosis in ovarian granulosa cells. Sci Rep. 2017 Jan 23; 7:41304.
https://www.nature.com/articles/srep41304
Liu X, Campanac E, Cheung HH, Ziats MN, Canterel-Thouennon L, Raygada M, Baxendale V, Pang AL, Yang L, Swedo S, Thurm A, Lee TL, Fung KP, Chan WY, Hoffman DA, Rennert OM. Idiopathic Autism: Cellular and Molecular Phenotypes in Pluripotent Stem Cell-Derived Neurons. Mol Neurobiol. 2016 Jun 29.
https://www.ncbi.nlm.nih.gov/pubmed/27356918
Yang Y, Cheung HH, Tu JJ, Miu KK, Chan WY. New insights into the unfolded protein response in stem cells. Oncotarget. 2016 Jun 6.
https://www.ncbi.nlm.nih.gov/pubmed/27304053
Yang Y, Cheung HH, Law WN, Zhang C, Chan WY, Pei X, Wang Y. New Insights into the Role of Autophagy in Ovarian Cryopreservation by Vitrification. Biol Reprod. 2016 Feb 24.
https://academic.oup.com/biolreprod/article/94/6/137,%201-6/2863964
Cheung HH, Yang Y, Lee TL, Rennert O, Chan WY. Hypermethylation of genes in testicular embryonal carcinomas. Br J Cancer. 2016 Jan 19. 114(2):230-6.
https://www.ncbi.nlm.nih.gov/pubmed/26625006
Cheung HH, Pei D, Chan WY. Stem cell aging in adult progeria. Cell Regen (Lond). 2015 Oct 3; 4:6.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592574/
Cheung HH, Liu X, Canterel-Thouennon L, Li L, Edmonson C, Rennert OM. Telomerase protects Werner Syndrome lineage-specific stem cells from premature aging. Stem Cell Reports, 2014 Mar 27; 2(4):534-46.
https://www.ncbi.nlm.nih.gov/pubmed/24749076
Gu S, Cheung HH, Lee TL, Lu G, Poon WS, Chan WY. Molecular Mechanisms of Regulation and Action of microRNA-199a in Testicular Germ Cell Tumor and Glioblastomas. PLoS One, 2013 Dec 31; 8(12):e83980.
https://www.ncbi.nlm.nih.gov/pubmed/24391856
Cheung HH, Liu X, Rennert OM. Apoptosis: Reprogramming and the Fate of Mature Cells. ISRN Cell Biology, 2012,
https://www.hindawi.com/journals/isrn/2012/685852/
Cheung HH, Lee TL, Rennert OM, Chan WY. Methylation profiling using methylated DNA immunoprecipitation and tiling array hybridization. Methods Mol Biol. 2012; 825:115-26.
https://www.ncbi.nlm.nih.gov/pubmed/22144241
Cheung HH, Rennert OM. Generation of fertile sperm in a culture dish: clinical implications. Asian J Androl. 2011 Jul; 13(4):618-9.
https://www.ncbi.nlm.nih.gov/pubmed/21642995
Cheung HH, Davis AJ, Lee TL, Pang AL, Nagrani S, Rennert OM, Chan WY. Methylation of an intronic region regulates miR-199a in testicular tumor malignancy. Oncogene. 2011 Aug 4; 30(31):3404-15.
https://www.ncbi.nlm.nih.gov/pubmed/21383689
Cheung HH, Lee TL, Davis AJ, Taft DH, Rennert OM, Chan WY. Genome-wide DNA methylation profiling reveals novel epigenetically regulated genes and non-coding RNAs in human testicular cancer. Br J Cancer. 2010 Jan 19; 102(2):419-27.
https://www.ncbi.nlm.nih.gov/pubmed/20051947
Lee TL, Li Y, Cheung HH, Claus J, Singh S, Sastry C, Rennert OM, Lau YF, Chan WY. GonadSAGE: a comprehensive SAGE database for transcript discovery on male embryonic gonad development. Bioinformatics. 2010 Feb 15; 26(4):585-6.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852216/
Cheung HH, Lee TL, Rennert OM, Chan WY. DNA methylation of cancer genome. Birth Defects Res C Embryo Today. 2009 Dec; 87(4):335-50.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940836/
Lee TL, Cheung HH, Claus J, Sastry C, Singh S, Vu L, Rennert O, Chan WY. GermSAGE: a comprehensive SAGE database for transcript discovery on male germ cell development. Nucleic Acids Res. 2009 Jan; 37 (Database issue):D891-7.
https://www.ncbi.nlm.nih.gov/pubmed/18832368
Co NN, Tsang WP, Wong TW, Cheung HH, Tsang TY, Kong SK, Kwok TT. Oncogene AF1q enhances doxorubicin-induced apoptosis through BAD-mediated mitochondrial apoptotic pathway. Mol Cancer Ther. 2008 Oct; 7(10):3160-8.
https://www.ncbi.nlm.nih.gov/pubmed/18852119
Tsang WP, Wong TW, Cheung AH, Co CN, Kwok TT. Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR. RNA. 2007 Jun; 13(6):890-8.
https://www.ncbi.nlm.nih.gov/pubmed/17416635
Yuxin Hou, Chang Li, Chaemin Yoon, On Wah Leung, Sikun You, Xiaoming Cui, Jasper Fuk-Woo Chan, Duanqing Pei, *Hoi Hung Cheung & *Hin Chu. Enhanced replication of SARS-CoV-2 Omicron BA.2 in human forebrain and midbrain organoids. Sig Transduct Target Ther 7, 381 (2022). (*co-corresponding authors)
https://doi.org/10.1038/s41392-022-01241-2
Yuyao Tian, Wuming Wang, Sofie Lautrup, Hui Zhao, Xiang Li, Patrick Wai Nok Law, Ngoc-Duy Dinh, Evandro Fei Fang, Hoi Hung Cheung & Wai-Yee Chan. WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome. Nat Commun 13, 5456 (2022).
https://doi.org/10.1038/s41467-022-33012-6
Zhaohui Liu & Hoi-Hung Cheung. Stem Cell-Based Therapies for Parkinson Disease. Int. J. Mol. Sci. 2020; 21(21):8060.
https://doi.org/10.3390/ijms21218060
Wang Z, Miu KK, Zhang X, Wan TY, Lu G, Cheung HH, Lee HM, Kong PS, Chan JCN & Chan WY. Hepatic miR-192-3p re-activation alleviates steatosis by targeting glucocorticoid receptor. JHEP Reports. 2020 Dec; 2(6)
https://doi.org/10.1016/j.jhepr.2020.100179
Jiajie Tu, Chao Wan, Fengjie Zhang, Yuyao Tian, Lianbao Cao, Patrick Wai Nok Law, Gang Lu, Owen M. Rennert, Wai-Yee Chan & Hoi-Hung Cheung. Genetic correction of Werner syndrome gene reveals impaired pro-angiogenic function and HGF insufficiency in mesenchymal stem cells. Aging Cell. 2020 May; 19(5):e13116.
https://doi.org/10.1111/acel.13116
Wuming WANG, Gang LU, Xianwei SU, Chengcheng TANG, Hongjian LI, Zhiqiang XIONG, Chi-Kwan LEUNG, Man-Sze WONG, Hongbin LIU, Jin-Long MA, Hoi-Hung Cheung, Hsiang-Fu KUNG, Zi-Jiang CHEN, Wai-Yee CHAN. Pten-mediated Gsk3β Modulates the Naïve Pluripotency Maintenance in Embryonic Stem Cells. Cell Death Dis. 2020 Feb 7; 11(2):107.
https://doi.org/10.1038/s41419-020-2271-0
Tu J, Cheung HH, Lu G, Chan CL, Chen ZJ, Chan WY. microRNA-126 Is a Tumor Suppressor of Granulosa Cell Tumor Mediated by Its Host Gene EGFL7. Front. Oncol. 11 June 2019.
https://doi.org/10.3389/fonc.2019.00486
Cao D, Cheung HH, Chan WY. Doxycycline masks the genuine effect of the doxycycline-inducible transgene by promoting dopaminergic neuron differentiation from human pluripotent stem cells. Stem Cells Dev. 2019 Apr 25.
https://www.liebertpub.com/doi/abs/10.1089/scd.2018.0209
Tu J, Cheung AH, Chan LK and Chan WY. The Role of microRNAs in Ovarian Granulosa Cells in Health and Diseases. Front. Endocrinol. 2019 Mar 1.
https://www.frontiersin.org/articles/10.3389/fendo.2019.00174/abstract
Sofie Lautrup, Domenica Caponio, Hoi-Hung Cheung, Claudia Piccoli, Tinna Stevnsner, Wai-Yee-Chan, Evandro F. Fang. Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases. Biogerontology. 2019 Jan
https://www.ncbi.nlm.nih.gov/pubmed/30666569
Tu J, Tian G, Cheung HH, Wei W, Lee TL. Gas5 is an essential lncRNA regulator for self-renewal and pluripotency of mouse embryonic stem cells and induced pluripotent stem cells. Stem Cell Res Ther. 2018 Mar 21;9(1):71.
https://www.ncbi.nlm.nih.gov/pubmed/29562912
Jiajie Tu, Hoi-Hung Cheung, Gang Lu, Zijiang Chen, Wai-Yee Chan. MicroRNA-10a promotes granulosa cells tumor development via PTEN-AKT/Wnt regulatory axis. Cell Death & Disease. 2018 Oct 22;9(11):1076.
https://www.nature.com/articles/s41419-018-1117-5
Jiajie Tu, Pengying Zhang, Alfred Chun Shui Luk, Jason Jinyue Liao, Wai-Yee Chan, Albert Cheung Hoi-Hung* and Tin-Lap Lee*. MicroRNA-26b promotes transition from Kit- to Kit+ mouse spermatogonia. Experimental cell research. 2018 Sep 25. pii: S0014-4827(18)30585-8. (*co-corresponding authors)
https://www.ncbi.nlm.nih.gov/pubmed/30266657
Yanzhou Yang, Hoi-Hung Cheung, Cheng Zhang, Ji Wu and Wai-Yee Chan. Melatonin as Potential Targets for Delaying Ovarian Aging. Curr Drug Targets. 2018 Aug 28.
https://www.ncbi.nlm.nih.gov/pubmed/30156157
Lu Li, Kai-Kei Miu, Shen Gu, *Hoi-Hung Cheung & *Wai-Yee Chan. Comparison of multi-lineage diferentiation of hiPSCs reveals novel miRNAs that regulate lineage specification. Sci Rep. 2018. 8:9630. (*co-corresponding authors)
https://www.nature.com/articles/s41598-018-27719-0
Jiajie Tu, Dandan Cao, Lu Li, *Hoi-Hung Cheung, *Wai-Yee Chan. MicroRNA profiling during directed differentiation of cortical interneurons from human-induced pluripotent stem cells. FEBS Openbio. 2018. (*co-corresponding authors)
https://febs.onlinelibrary.wiley.com/doi/full/10.1002/2211-5463.12377
Tu Jiajie, Yang Yanzhou, Cheung Hoi-Hung, Chen Zi-Jiang & Chan Wai-Yee. Conserved miR-10 family represses proliferation and induces apoptosis in ovarian granulosa cells. Sci Rep. 2017 Jan 23; 7:41304.
https://www.nature.com/articles/srep41304
Liu X, Campanac E, Cheung HH, Ziats MN, Canterel-Thouennon L, Raygada M, Baxendale V, Pang AL, Yang L, Swedo S, Thurm A, Lee TL, Fung KP, Chan WY, Hoffman DA, Rennert OM. Idiopathic Autism: Cellular and Molecular Phenotypes in Pluripotent Stem Cell-Derived Neurons. Mol Neurobiol. 2016 Jun 29.
https://www.ncbi.nlm.nih.gov/pubmed/27356918
Yang Y, Cheung HH, Tu JJ, Miu KK, Chan WY. New insights into the unfolded protein response in stem cells. Oncotarget. 2016 Jun 6.
https://www.ncbi.nlm.nih.gov/pubmed/27304053
Yang Y, Cheung HH, Law WN, Zhang C, Chan WY, Pei X, Wang Y. New Insights into the Role of Autophagy in Ovarian Cryopreservation by Vitrification. Biol Reprod. 2016 Feb 24.
https://academic.oup.com/biolreprod/article/94/6/137,%201-6/2863964
Cheung HH, Yang Y, Lee TL, Rennert O, Chan WY. Hypermethylation of genes in testicular embryonal carcinomas. Br J Cancer. 2016 Jan 19. 114(2):230-6.
https://www.ncbi.nlm.nih.gov/pubmed/26625006
Cheung HH, Pei D, Chan WY. Stem cell aging in adult progeria. Cell Regen (Lond). 2015 Oct 3; 4:6.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592574/
Cheung HH, Liu X, Canterel-Thouennon L, Li L, Edmonson C, Rennert OM. Telomerase protects Werner Syndrome lineage-specific stem cells from premature aging. Stem Cell Reports, 2014 Mar 27; 2(4):534-46.
https://www.ncbi.nlm.nih.gov/pubmed/24749076
Gu S, Cheung HH, Lee TL, Lu G, Poon WS, Chan WY. Molecular Mechanisms of Regulation and Action of microRNA-199a in Testicular Germ Cell Tumor and Glioblastomas. PLoS One, 2013 Dec 31; 8(12):e83980.
https://www.ncbi.nlm.nih.gov/pubmed/24391856
Cheung HH, Liu X, Rennert OM. Apoptosis: Reprogramming and the Fate of Mature Cells. ISRN Cell Biology, 2012,
https://www.hindawi.com/journals/isrn/2012/685852/
Cheung HH, Lee TL, Rennert OM, Chan WY. Methylation profiling using methylated DNA immunoprecipitation and tiling array hybridization. Methods Mol Biol. 2012; 825:115-26.
https://www.ncbi.nlm.nih.gov/pubmed/22144241
Cheung HH, Rennert OM. Generation of fertile sperm in a culture dish: clinical implications. Asian J Androl. 2011 Jul; 13(4):618-9.
https://www.ncbi.nlm.nih.gov/pubmed/21642995
Cheung HH, Davis AJ, Lee TL, Pang AL, Nagrani S, Rennert OM, Chan WY. Methylation of an intronic region regulates miR-199a in testicular tumor malignancy. Oncogene. 2011 Aug 4; 30(31):3404-15.
https://www.ncbi.nlm.nih.gov/pubmed/21383689
Cheung HH, Lee TL, Davis AJ, Taft DH, Rennert OM, Chan WY. Genome-wide DNA methylation profiling reveals novel epigenetically regulated genes and non-coding RNAs in human testicular cancer. Br J Cancer. 2010 Jan 19; 102(2):419-27.
https://www.ncbi.nlm.nih.gov/pubmed/20051947
Lee TL, Li Y, Cheung HH, Claus J, Singh S, Sastry C, Rennert OM, Lau YF, Chan WY. GonadSAGE: a comprehensive SAGE database for transcript discovery on male embryonic gonad development. Bioinformatics. 2010 Feb 15; 26(4):585-6.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852216/
Cheung HH, Lee TL, Rennert OM, Chan WY. DNA methylation of cancer genome. Birth Defects Res C Embryo Today. 2009 Dec; 87(4):335-50.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940836/
Lee TL, Cheung HH, Claus J, Sastry C, Singh S, Vu L, Rennert O, Chan WY. GermSAGE: a comprehensive SAGE database for transcript discovery on male germ cell development. Nucleic Acids Res. 2009 Jan; 37 (Database issue):D891-7.
https://www.ncbi.nlm.nih.gov/pubmed/18832368
Co NN, Tsang WP, Wong TW, Cheung HH, Tsang TY, Kong SK, Kwok TT. Oncogene AF1q enhances doxorubicin-induced apoptosis through BAD-mediated mitochondrial apoptotic pathway. Mol Cancer Ther. 2008 Oct; 7(10):3160-8.
https://www.ncbi.nlm.nih.gov/pubmed/18852119
Tsang WP, Wong TW, Cheung AH, Co CN, Kwok TT. Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR. RNA. 2007 Jun; 13(6):890-8.
https://www.ncbi.nlm.nih.gov/pubmed/17416635